New Study: Bed Rest Impairs Skeletal Muscle Oxidative Metabolism

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Desy Salvadego and colleagues have published a new paper ahead of print in the Journal of Applied Physiology suggesting that prolonged sedentary behaviour may impair oxidative function in skeletal muscle.

From the abstract:

A functional evaluation of skeletal muscle oxidative metabolism during dynamic knee-extension (KE) incremental exercises was carried out following a 35-day bed rest (BR) (Valdoltra 2008 BR campaign). Nine young male volunteers (age: 23.5 ± 2.2 years [mean ± SD]) were evaluated. Pulmonary gas exchange, heart rate (HR) and cardiac output (Q, by impedance cardiography), skeletal muscle (vastus lateralis) fractional O2 extraction and brain (frontal cortex) oxygenation (by near-infrared spectroscopy) were determined during incremental KE. Values at exhaustion were considered “peak”. Peak HR (147 ± 18 beats.min-1 before vs. 146 ± 17 after BR) and peak (17.8 ± 3.3 L.min-1 before vs. 16.1 ± 1.8 after BR) were unaffected by BR. As expected, brain oxygenation did not decrease during KE. Peak O2 uptake (VO 2peak) was lower after vs. before BR, both when expressed as L.min-1 (0.99 ± 0.17 vs. 1.26 ± 0.27) and when normalized per unit of quadriceps muscle mass (46.5 ± 6.4 mL.min-1.100g-1 vs. 56.9 ± 11.0). Skeletal muscle peak fractional O2 extraction, expressed as a percentage of the maximal values obtained during a transient limb ischemia, was lower after (46.3 ± 12.1%) vs. before BR (66.5 ± 11.2). After eliminating, by the adopted exercise protocol, constraints related to cardiovascular O2 delivery, a decrease in VO 2peak and muscle peak capacity of fractional O2 extraction was found after 35 days of BR. These findings suggest a substantial impairment of oxidative function at the muscle level, “downstream” with respect to bulk blood flow to the exercising muscles, that is possibly at the level of blood flow distribution/O2 utilization inside the muscle, peripheral O2 diffusion, intracellular oxidative metabolism.

The full study can be accessed via the Journal of Applied Physiology website here.  Thanks to Patrice Brassard of Le Physiologiste for pointing out this interesting new study.

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